Remove pork from fridge 20–30 minutes before cooking to reach room temperature.
Pat pork dry and trim any silver skin using a sharp knife.
Season all sides with salt, pepper, and garlic powder.
Preheat oven to 400°F while preparing glaze.
In a saucepan, combine honey, brown sugar, soy sauce, garlic, mustard, and vinegar.
Simmer 3–4 minutes until slightly thickened, then reserve ¼ cup for later.
Heat olive oil in a cast iron skillet; sear pork 2–3 minutes per side until golden.
Brush pork with half the glaze and transfer skillet to oven.
Roast 15–20 minutes or until internal temp reaches 145°F.
Remove from oven, brush with remaining glaze, and rest 5–10 minutes.
Slice into ½-inch medallions and drizzle with pan juices.